Đăng xuất
Method of administration: Risperidone: Take one daily or twice daily. Taken on full or empty stomach, food does not affect the gastrointestinal absorption of risperidone. If drowsy, drink 1 time at bedtime. Remove the tablet from the blister, immediately place it on the tongue, do not need to drink with water.
Or drop the tablet into a glass of water, and drink immediately.
Posology: Schizophrenia: Adults, the first dose on the first day: 2 mg orally once or twice a day.
The second day: 4 mg orally once or twice a day.
The third day: 6 mg orally once or twice a day.
From 4th day, the maintenance dose will unchange or adjust according to the patient as needed.
Usual optimal dosage: 4 - 8 mg/day orally once or twice a day. However, recent clinical experience has shown that the more appropriate dose for the treatment of the majority of healthy patients with schizophrenia is as follows: Initial dose 1-2 mg/day, gradually increasing daily dose to 0.5-1 mg over 6-7 days, if tolerated, to target dose of 4 mg/day. Dosage adjustments must be made at least 7 days apart.
For young adults and for first-timers, the initial dose may be lower (eg, 1 mg/day) and titrated more slowly up to the first target dose of 2 mg/day; The dose may then be titrated up to 4 mg/day according to clinical response to achieve the smallest effective dose. These patients usually have an optimal dose of risperidone 1 to 3 mg/day. Some patients on first-line therapy began to have extrapyramidal symptoms once the dose was increased above 2 mg/day. Dosage should be reduced at the onset of extrapyramidal symptoms.
Patients need to be evaluated periodically to decide whether to continue treatment.
Bipolar disease: Treatment of manic and mixed episodes of bipolar disease: Take the first dose of 2 - 3 mg orally once daily. The dose may be increased or decreased by 1 mg/day at intervals of not less than 24 hours.
If treatment exceeds 3 weeks, periodically assess the risks of prolonged therapy and the benefits of the drug for each patient.
Autism with behavioral disorders in children aged 5 years and older: The first dose is 0.25 mg/day for children weighing less than 20 kg and 0.5 mg/day for children weighing 20kg or more. The drug can be given once or twice a day. Dosage is adjusted according to the response and tolerability of each patient. At least 4 days after the first dose, the dose may be increased to the recommended dose of 0.5 mg/day for children weighing < 20 kg and 1 mg/day for children weighing 20 kg or more. Then this dose is maintained for a minimum of 14 days. For patients who do not respond satisfactorily, the dose may be increased at intervals of 2 weeks or more in increments of 0.25 mg/day for patients weighing < 20 kg or 0.5 mg/day for those who patients weighing 20 kg or more.
Dosage in renal and hepatic impairment, the elderly, or those at risk for orthostatic hypotension: Because the elimination of risperidone may be reduced and the risk of adverse effects, especially orthostatic hypotension, is increased in patients with renal impairment and in the elderly, risperidone therapy should be initiated at a reduced dose, 0.5 mg, once or twice a day and increased as needed and as tolerated, in increments not exceeding 0.5 mg, twice daily; Dose increases beyond 1.5 mg, twice daily, must be done at an interval of at least 7 days. Some clinicians recommend an initial dose of 0.25 mg/day and gradually increased as tolerated in the elderly. The dose should not be maintained in excess of 3 mg/day in the elderly. Dosage reduction is also required in patients with hepatic impairment because of the increased risk of free risperidone in these patients.
